Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89136
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
2300±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89136
Synonyms:
MLS-0299362.0001 | N-[(E)-[(E)-2-chloranyl-3-phenyl-prop-2-enylidene]amino]thiophene-2-carboxamide | N-[(E)-[(E)-2-chloro-3-phenyl-prop-2-enylidene]amino]thiophene-2-carboxamide | N-[(E)-[(E)-2-chloro-3-phenylprop-2-enylidene]amino]-2-thiophenecarboxamide | N-[(E)-[(E)-2-chloro-3-phenylprop-2-enylidene]amino]thiophene-2-carboxamide | cid_6861718
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2OS
Mol. Mass.:
290.768
SMILES:
Cl\C(\C=N\NC(=O)c1cccs1)=C\c1ccccc1
Structure:
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