Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM89501
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay - Set 2
EC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay - Set 2 PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM89501
Synonyms:
2-methyl-3-(3,4,5-trimethyl-1-pyrazolyl)propanoic acid | 2-methyl-3-(3,4,5-trimethylpyrazol-1-yl)propanoic acid | 2-methyl-3-(3,4,5-trimethylpyrazol-1-yl)propionic acid | MLS-0466814.0001 | cid_3162903
Type:
Small organic molecule
Emp. Form.:
C10H16N2O2
Mol. Mass.:
196.2462
SMILES:
CC(Cn1nc(C)c(C)c1C)C(O)=O
Structure:
Search PDB for entries with ligand similarity: