Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM89504
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay - Set 2
EC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay - Set 2 PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM89504
Synonyms:
3-(1-benzotriazolyl)-2-methylpropanoic acid | 3-(benzotriazol-1-yl)-2-methyl-propanoic acid | 3-(benzotriazol-1-yl)-2-methyl-propionic acid | 3-(benzotriazol-1-yl)-2-methylpropanoic acid | MLS-0284654.0001 | cid_2913712
Type:
Small organic molecule
Emp. Form.:
C10H11N3O2
Mol. Mass.:
205.2132
SMILES:
CC(Cn1nnc2ccccc12)C(O)=O
Structure:
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