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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90282
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
1830±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90282
Synonyms:
2-[(4-fluorophenyl)sulfonylamino]-N-(2-hydroxy-5-piperidin-1-ylsulfonylphenyl)benzamide;hydrochloride | 2-[(4-fluorophenyl)sulfonylamino]-N-(2-hydroxy-5-piperidinosulfonyl-phenyl)benzamide;hydrochloride | 2-[(4-fluorophenyl)sulfonylamino]-N-(2-oxidanyl-5-piperidin-1-ylsulfonyl-phenyl)benzamide;hydrochloride | 2-[(4-fluorophenyl)sulfonylamino]-N-[2-hydroxy-5-(1-piperidinylsulfonyl)phenyl]benzamide;hydrochloride | MLS000336682 | SMR000243997 | cid_15945362
Type:
Small organic molecule
Emp. Form.:
C24H24FN3O6S2
Mol. Mass.:
533.592
SMILES:
Oc1ccc(cc1NC(=O)c1ccccc1NS(=O)(=O)c1ccc(F)cc1)S(=O)(=O)N1CCCCC1
Structure:
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