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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90590
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
2840±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90590
Synonyms:
4,4-dimethyl-N-(phenylmethyl)-5H-1,3-thiazol-2-amine | 4,4-dimethyl-N-(phenylmethyl)-5H-thiazol-2-amine | MLS001003954 | N-benzyl-4,4-dimethyl-5H-1,3-thiazol-2-amine | SMR000347729 | benzyl-(4,4-dimethyl-2-thiazolin-2-yl)amine | cid_2376018
Type:
Small organic molecule
Emp. Form.:
C12H16N2S
Mol. Mass.:
220.334
SMILES:
CC1(C)CSC(NCc2ccccc2)=N1 |c:14|
Structure:
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