Reaction Details Report a problem with these data
Target
Soluble acetylcholine receptor
Ligand
BDBM91624
Substrate
n/a
Meas. Tech.
Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates.
pH
7.4±n/a
Temperature
293.15±n/a K
Ki
16±n/a nM
Citation
 Yamauchi, JG; Gomez, K; Grimster, N; Dufouil, M; Nemecz, A; Fotsing, JR; Ho, K; Talley, TT; Sharpless, K; Fokin, VV; Taylor, P Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates. Mol Pharmacol 82:687-699 (2014) [PubMed]  Article 
Target
Name:
Soluble acetylcholine receptor
Synonyms:
Acetylcholine Binding protein | Soluble acetylcholine receptor
Type:
n/a
Mol. Mass.:
26560.08
Organism:
Aplysia Californica
Description:
Q8WSF8
Residue:
236
Sequence:
MLVSVYLALLVACVGQAHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVKADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAVKFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVVKFRERRAGNGFFRNLFD
  
Inhibitor
Name:
BDBM91624
Synonyms:
alpha7 agonists 4t
Type:
n/a
Emp. Form.:
C21H25N5O2
Mol. Mass.:
379.4555
SMILES:
CN1[C@H]2CC[C@@H]1C[C@H](C2)n1cc(COc2cc(=O)n(C)c3ccccc23)nn1 |THB:9:7:4.3:1|
Structure:
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