Reaction Details Report a problem with these data
Target
Serum paraoxonase/arylesterase 1
Ligand
BDBM92332
Substrate
n/a
Meas. Tech.
Paraoxonase Activity Assay
pH
10.5±0
Temperature
298.15±0 K
Ki
306000±0.0 nM
IC50
340000±0.0 nM
Citation
 Ekinci, D; Beydemir, S Effect of some analgesics on paraoxonase-1 purified from human serum. J Enzyme Inhib Med Chem 24:1034-9 (2009) [PubMed]  Article 
Target
Name:
Serum paraoxonase/arylesterase 1
Synonyms:
A-esterase 1 | Aromatic esterase 1 | K-45 | PON | PON 1 | PON1 | PON1_HUMAN | Paraoxonase (PON1) | Paraoxonase (hPON1) | Paraoxonase 1 (PON1) | Serum aryldialkylphosphatase 1 | Serum paraoxonase 1 (PON1)
Type:
Enzyme
Mol. Mass.:
39719.73
Organism:
Homo sapiens (Human)
Description:
P27169
Residue:
355
Sequence:
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
  
Inhibitor
Name:
BDBM92332
Synonyms:
Tenoxicam
Type:
Small organic molecule
Emp. Form.:
C13H11N3O4S2
Mol. Mass.:
337.374
SMILES:
CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O |t:12|
Structure:
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