Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPapain
LigandBDBM92336
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH6.5±0
Temperature298.15±0 K
Ki 1.1e+3± 1e+2 nM
Citation Löser, RGütschow, M Dipeptide-derived nitriles containing additional electrophilic sites: potentially irreversible inhibitors of cysteine proteases. J Enzyme Inhib Med Chem24:1245-52 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Papain
Name:Papain
Synonyms:Allergen=Car p 1 | PPI | Papaya proteinase I
Type:Enzyme
Mol. Mass.:38923.01
Organism:Carica papaya
Description:Papain was purchased from Sigma, Germany.
Residue:345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYK
NIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTE
LSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNE
YSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKT
DGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYG
PNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM92336
NameBDBM92336
Synonyms:Dipeptide nitrile, 10
TypeSmall organic molecule
Emp. Form.C18H22N4O3
Mol. Mass.342.3923
SMILESCC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC#N)C#N |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a