Reaction Details Report a problem with these data
Target
Trehalose synthase/amylase TreS
Ligand
BDBM92460
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
2.5e+3±n/a nM
Citation
 Zhang, R; Pan, YT; He, S; Lam, M; Brayer, GD; Elbein, AD; Withers, SG Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis. J Biol Chem 286:35601-9 (2011) [PubMed]  Article 
Target
Name:
Trehalose synthase/amylase TreS
Synonyms:
Maltose alpha-D-glucosyltransferase | TRES_MYCTO | Trehalose Synthase (TreS) | treS
Type:
Protein
Mol. Mass.:
68564.96
Organism:
Mycobacterium tuberculosis
Description:
P9WQ18
Residue:
601
Sequence:
MNEAEHSVEHPPVQGSHVEGGVVEHPDAKDFGSAAALPADPTWFKHAVFYEVLVRAFFDASADGSGDLRGLIDRLDYLQWLGIDCIWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTEESNWSFDPVRRQFYWHRFFSHQPDLNYDNPAVQEAMIDVIRFWLGLGIDGFRLDAVPYLFEREGTNCENLPETHAFLKRVRKVVDDEFPGRVLLAEANQWPGDVVEYFGDPNTGGDECHMAFHFPLMPRIFMAVRRESRFPISEIIAQTPPIPDMAQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANVGIRRRLAPLLDNDRNQIELFTALLLSLPGSPVLYYGDEIGMGDVIWLGDRDGVRIPMQWTPDRNAGFSTANPGRLYLPPSQDPVYGYQAVNVEAQRDTSTSLLNFTRTMLAVRRRHPAFAVGAFQELGGSNPSVLAYVRQVAGDDGDTVLCVNNLSRFPQPIELDLQQWTNYTPVELTGHVEFPRIGQVPYLLTLPGHGFYWFQLTTHEVGAPPTCGGERRL
  
Inhibitor
Name:
BDBM92460
Synonyms:
Casuarine
Type:
Small organic molecule
Emp. Form.:
C8H15NO5
Mol. Mass.:
205.2084
SMILES:
OC[C@@H]1[C@@H](O)[C@H](O)[C@H]2[C@H](O)[C@@H](O)CN12
Structure:
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