Reaction Details Report a problem with these data
Target
Peptide deformylase
Ligand
BDBM92761
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
117±0.0 nM
Citation
 Totoritis, R; Duraiswami, C; Taylor, AN; Kerrigan, JJ; Campobasso, N; Smith, KJ; Ward, P; King, BW; Murrayz-Thompson, M; Jones, AD; Van Aller, GS; Aubart, KM; Zalacain, M; Thrall, SH; Meek, TD; Schwartz, B Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors. Biochemistry 50:6642-54 (2011) [PubMed]  Article 
Target
Name:
Peptide deformylase
Synonyms:
DEF_STRR6 | PDF | Polypeptide Deformylase | Polypeptide deformylase (PDF) | def
Type:
Enzyme
Mol. Mass.:
22684.24
Organism:
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Description:
The pdf gene from S. pneumoniae was cloned and protein was expressed and purified from E. coli BL21(DE3).
Residue:
203
Sequence:
MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEAYDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
  
Inhibitor
Name:
BDBM92761
Synonyms:
PDF inhibitor, compound 3
Type:
Small molecule
Emp. Form.:
C27H32ClN9O2S
Mol. Mass.:
582.12
SMILES:
CNC(=O)[C@@H]1CSCN1c1nc(Nc2c(C)cccc2C(=O)NC)nc(n1)N1CCN(CC1)c1ccccc1Cl |r|
Structure:
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