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Target
Aurora kinase B
Ligand
BDBM92831
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Assay
IC50
180±0 nM
Citation
 Lawrence, HR; Martin, MP; Luo, Y; Pireddu, R; Yang, H; Gevariya, H; Ozcan, S; Zhu, JY; Kendig, R; Rodriguez, M; Elias, R; Cheng, JQ; Sebti, SM; Schonbrunn, E; Lawrence, NJ Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors. J Med Chem 55:7392-416 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM92831
Synonyms:
Bisanilinopyrimidine, 9d | US9249124, 47
Type:
Small molecule
Emp. Form.:
C17H15ClN4O2S
Mol. Mass.:
374.845
SMILES:
CS(=O)(=O)c1ccc(Nc2nccc(Nc3ccccc3Cl)n2)cc1
Structure:
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