Reaction Details Report a problem with these data
Target
Bifunctional aspartokinase/homoserine dehydrogenase 1
Ligand
BDBM17657
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
38000000±1000000 nM
Citation
 Angeles, TS; Hunsley, JR; Viola, RE Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli. Biochemistry 31:799-805 (1992) [PubMed]  Article 
Target
Name:
Bifunctional aspartokinase/homoserine dehydrogenase 1
Synonyms:
AK1H_ECOLI | Aspartokinase I | Bifunctional aspartokinase/homoserine dehydrogenase 1 | thrA | thrA1 | thrA2
Type:
Protein
Mol. Mass.:
89109.15
Organism:
Escherichia coli
Description:
P00561
Residue:
820
Sequence:
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDALPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINAALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIPADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQVPDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRDEDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISFCVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAALARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRLVKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLAREMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
  
Inhibitor
Name:
BDBM17657
Synonyms:
(2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutamate | Glutamate | L-Glu | L-Glutamate | L-Glutamic acid | L-[14C(U)]glutamate | L-gluatmate
Type:
Amino Acid
Emp. Form.:
C5H9NO4
Mol. Mass.:
147.1293
SMILES:
N[C@@H](CCC(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: