Reaction Details Report a problem with these data
Target
Anthranilate phosphoribosyltransferase
Ligand
BDBM93075
Substrate
n/a
Meas. Tech.
Fluoresence-based Assay
Ki
1.5e+4± 4e+3 nM
Citation
 Castell, A; Short, FL; Evans, GL; Cookson, TV; Bulloch, EM; Joseph, DD; Lee, CE; Parker, EJ; Baker, EN; Lott, JS The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry 52:1776-1787 (2013) [PubMed]  Article 
Target
Name:
Anthranilate phosphoribosyltransferase
Synonyms:
Anthranilate phosphoribosyltransferase (Mtb-AnPRT) | TRPD_MYCTO | trpD
Type:
Enzyme
Mol. Mass.:
37738.87
Organism:
Mycobacterium tuberculosis
Description:
P9WFX4
Residue:
370
Sequence:
MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
  
Inhibitor
Name:
BDBM93075
Synonyms:
ACS No 145
Type:
Small molecule
Emp. Form.:
C9H10NO4
Mol. Mass.:
196.1805
SMILES:
COc1cc(N)c(cc1OC)C([O-])=O
Structure:
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