Target
Anthranilate phosphoribosyltransferase
Ligand
BDBM93077
Substrate
n/a
Meas. Tech.
Fluoresence-based Assay
Ki
1.9e+4± 5e+3 nM
Citation
 Castell, AShort, FLEvans, GLCookson, TVBulloch, EMJoseph, DDLee, CEParker, EJBaker, ENLott, JS The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry 52:1776-1787 (2013) [PubMed]  Article 
Target
Name:
Anthranilate phosphoribosyltransferase
Synonyms:
Anthranilate phosphoribosyltransferase (Mtb-AnPRT) | TRPD_MYCTO | trpD
Type:
Enzyme
Mol. Mass.:
37738.87
Organism:
Mycobacterium tuberculosis
Description:
P9WFX4
Residue:
370
Sequence:
MALSAEGSSGGSRGGSPKAEAASVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
  
Inhibitor
Name:
BDBM93077
Synonyms:
ACS No 179
Type:
Small molecule
Emp. Form.:
C17H10NO7
Mol. Mass.:
340.2643
SMILES:
COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C([O-])=O
Structure:
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