Target

Ligand

Substrate

Meas. Tech.

Kinase Inhibition Assay

Citation

 Thompson, AM; Rewcastle, GW; Tercel, M; Dobrusin, EM; Fry, DW; Kraker, AJ; Denny, WA Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids). J Med Chem 36:2459-69 (1993) [PubMed]  Article Copy BDB DOI

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Name:

Epidermal growth factor receptor

Synonyms:

EGF Receptor Substrate | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal Growth Factor Receptor Tyrosine Kinase | Epidermal Growth Factor Receptor erbB-1 | Epidermal Growth Factor Receptor, ErbB-1 | Epidermal growth factor receptor (EGFR) | Epidermal growth factor receptor (HER1) | HER1 | Protein-Tyrosine Kinase Erbb-1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase ErbB-1 | Tyrosine-Protein Kinase ErbB-1

Type:

Receptor Kinase Domain

Mol. Mass.:

134279.59

Organism:

Homo sapiens (Human)

Description:

P00533

Residue:

1210

Sequence:

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA

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Name:

BDBM3983

Synonyms:

2,2 -Dithiobis(5-methyl-1H-indole-3-propanoic acid) | 3-(2-{[3-(2-carboxyethyl)-5-methyl-1H-indol-2-yl]disulfanyl}-5-methyl-1H-indol-3-yl)propanoic acid | dithiobis(1H-indole-3-alkanoic acid) deriv. 31

Type:

Small organic molecule

Emp. Form.:

C24H24N2O4S2

Mol. Mass.:

468.588

SMILES:

Cc1ccc2[nH]c(SSc3[nH]c4ccc(C)cc4c3CCC(O)=O)c(CCC(O)=O)c2c1

Structure:

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Similarity to this molecule at least:

Name:

poly(E, A, Y)

Synonyms:

n/a

Type:

Random Polymer

Mol. Mass.:

358.43

Organism:

n/a

Description:

A 6:3:1 random copolymer of glutamate, alanine and tyrosine. 5 uM ATP containing 0.2 uCi of 0.5-3 Ci/mmol 32P labeled ATP.

Residue:

3

Sequence:

NA