Reaction Details Report a problem with these data
Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM49500
Substrate
n/a
IC50
2859±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM49500
Synonyms:
MLS000324854 | N-(3-cinnamoylphenyl)propanamide | N-[3-[(E)-1-oxo-3-phenylprop-2-enyl]phenyl]propanamide | N-[3-[(E)-3-phenylacryloyl]phenyl]propionamide | N-[3-[(E)-3-phenylprop-2-enoyl]phenyl]propanamide | SMR000161086 | cid_5895840
Type:
Small organic molecule
Emp. Form.:
C18H17NO2
Mol. Mass.:
279.3331
SMILES:
CCC(=O)Nc1cccc(c1)C(=O)\C=C\c1ccccc1
Structure:
Search PDB for entries with ligand similarity: