Reaction Details
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ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM94681
Substrate
n/a
IC50
17673±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
Inhibitor
Name:
BDBM94681
Synonyms:
1-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-2-[1-(2,4-dimethoxy-phenyl)-1H-tetrazol-5-ylsulfanyl]-ethanone | 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[1-(2,4-dimethoxyphenyl)tetrazol-5-yl]sulfanylethanone | 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[1-(2,4-dimethoxyphenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanone | 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[1-(2,4-dimethoxyphenyl)-5-tetrazolyl]thio]ethanone | 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[1-(2,4-dimethoxyphenyl)tetrazol-5-yl]thio]ethanone | MLS000030984 | SMR000003513 | cid_654798
Type:
Small organic molecule
Emp. Form.:
C19H18N4O5S
Mol. Mass.:
414.435
SMILES:
COc1ccc(c(OC)c1)-n1nnnc1SCC(=O)c1ccc2OCCOc2c1
Structure:
