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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM88864
Substrate
n/a
IC50
23837±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM88864
Synonyms:
2-(2,4-Dichloro-benzylsulfanyl)-6,7,8,9-tetrahydro-pyrimido[4,5-b]quinolin-4-ylamine | 2-[(2,4-dichlorophenyl)methylsulfanyl]-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4-amine | 2-[(2,4-dichlorophenyl)methylthio]-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4-amine | MLS000589160 | SMR000219822 | [2-[(2,4-dichlorobenzyl)thio]-6,7,8,9-tetrahydropyrimido[4,5-b]quinolin-4-yl]amine | cid_1992940
Type:
Small organic molecule
Emp. Form.:
C18H16Cl2N4S
Mol. Mass.:
391.317
SMILES:
Nc1nc(SCc2ccc(Cl)cc2Cl)nc2nc3CCCCc3cc12
Structure:
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