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Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM69756
Substrate
n/a
IC50
98439±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM69756
Synonyms:
4-[(2-pyridin-4-yl-4-quinazolinyl)amino]benzoic acid methyl ester | 4-[[2-(4-pyridyl)quinazolin-4-yl]amino]benzoic acid methyl ester | MLS001165380 | SMR000539993 | cid_1867461 | methyl 4-[(2-pyridin-4-ylquinazolin-4-yl)amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C21H16N4O2
Mol. Mass.:
356.3773
SMILES:
COC(=O)c1ccc(Nc2nc(nc3ccccc23)-c2ccncc2)cc1
Structure:
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