Reaction Details Report a problem with these data
Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95224
Substrate
n/a
IC50
34293±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95224
Synonyms:
MLS001146387 | N-[(E)-[3-(4-bromobenzyl)-4-chloro-2-keto-4-thiazolin-5-yl]methyleneamino]-2-furamide | N-[(E)-[3-[(4-bromophenyl)methyl]-4-chloranyl-2-oxidanylidene-1,3-thiazol-5-yl]methylideneamino]furan-2-carboxamide | N-[(E)-[3-[(4-bromophenyl)methyl]-4-chloro-2-oxo-1,3-thiazol-5-yl]methylideneamino]furan-2-carboxamide | N-[(E)-[3-[(4-bromophenyl)methyl]-4-chloro-2-oxo-5-thiazolyl]methylideneamino]-2-furancarboxamide | SMR000646826 | cid_6880175
Type:
Small organic molecule
Emp. Form.:
C16H11BrClN3O3S
Mol. Mass.:
440.699
SMILES:
Clc1c(\C=N\NC(=O)c2ccco2)sc(=O)n1Cc1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: