Reaction Details Report a problem with these data
Target
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95236
Substrate
n/a
IC50
28386±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] 
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
  
Inhibitor
Name:
BDBM95236
Synonyms:
1-methyl-3-indolecarboxylic acid [2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl] ester | 1-methylindole-3-carboxylic acid [2-(3,5-dimethylpiperidino)-2-keto-ethyl] ester | MLS002163378 | SMR001245767 | [2-(3,5-dimethylpiperidin-1-yl)-2-oxidanylidene-ethyl] 1-methylindole-3-carboxylate | [2-(3,5-dimethylpiperidin-1-yl)-2-oxoethyl] 1-methylindole-3-carboxylate | cid_16279788
Type:
Small organic molecule
Emp. Form.:
C19H24N2O3
Mol. Mass.:
328.4055
SMILES:
CC1CC(C)CN(C1)C(=O)COC(=O)c1cn(C)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: