Reaction Details
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Report a problem with these dataTarget
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM95608
Substrate
n/a
IC50
2491±n/a nM
Citation
PubChem, PC Luminescence-based cell-based high throughput dose response assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) PubChem Bioassay (2013)[AID] More Info.:
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
Inhibitor
Name:
BDBM95608
Synonyms:
2-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-oxidanylidene-pyrazin-2-yl]sulfanyl-N-(4-ethoxyphenyl)ethanamide | 2-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-oxopyrazin-2-yl]sulfanyl-N-(4-ethoxyphenyl)acetamide | 2-[[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-keto-pyrazin-2-yl]thio]-N-p-phenetyl-acetamide | 2-[[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-oxo-2-pyrazinyl]thio]-N-(4-ethoxyphenyl)acetamide | MLS001236962 | SMR000812488 | cid_18579402
Type:
Small organic molecule
Emp. Form.:
C22H21N3O5S
Mol. Mass.:
439.484
SMILES:
CCOc1ccc(NC(=O)CSc2nccn(-c3ccc4OCCOc4c3)c2=O)cc1
Structure:
