Reaction Details Report a problem with these data
Target
Enoyl-acyl carrier reductase
Ligand
BDBM8726
Substrate
n/a
Meas. Tech.
Fabl Assay
pH
7.4±0
IC50
49±n/a nM
Citation
 Samal, RP; Khedkar, VM; Pissurlenkar, RR; Bwalya, AG; Tasdemir, D; Joshi, RA; Rajamohanan, PR; Puranik, VG; Coutinho, EC Design, Synthesis, Structural Characterization by IR, (1) H, (13) C, (15) N, 2D-NMR, X-Ray Diffraction and Evaluation of a New Class of Phenylaminoacetic Acid Benzylidene Hydrazines as pfENR Inhibitors. Chem Biol Drug Des 81:715-29 (2013) [PubMed]  Article 
Target
Name:
Enoyl-acyl carrier reductase
Synonyms:
Enoyl-ACP reductase (ENR)
Type:
Protein
Mol. Mass.:
49835.97
Organism:
Plasmodium falciparum
Description:
Q9BH77
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTIVCFIQNNTQKTFHNVLHNEQIRGKEKAFYRKEKRENIFIGNKMKHLNNMNNTHNNNHYMEKEEQDASNIYKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM8726
Synonyms:
5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35
Type:
Small organic molecule
Emp. Form.:
C12H7Cl3O2
Mol. Mass.:
289.542
SMILES:
Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: