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Target
Aurora kinase B [2-344]/Inner centromere protein [826-918]
Ligand
BDBM50419247
Substrate
n/a
Meas. Tech.
Aurora B Enzyme Assay
pH
8±n/a
Temperature
303.15±n/a K
IC50
2.0e+4±n/a nM
Comments
extracted
Citation
 Atkinson, FL; Patel, VK Pyrimidinecarboxamide derivatives as inhibitors of Syk kinase US Patent  US8470835 Publication Date 6/25/2013 
Target
Name:
Aurora kinase B [2-344]/Inner centromere protein [826-918]
Synonyms:
Aurora B/INCENP
Type:
n/a
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 0 components.
Component 1
Name:
Aurora kinase B [2-344]
Synonyms:
AIK2 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Recombinant human Aurora B (aa 2-344) | STK1 | STK12 | STK5
Type:
Protein
Mol. Mass.:
39196.52
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
343
Sequence:
AQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Component 2
Name:
Inner centromere protein [826-918]
Synonyms:
INCENP | INCE_HUMAN | Inner centromere protein (INCENP)
Type:
Protein
Mol. Mass.:
10562.38
Organism:
Homo sapiens (Human)
Description:
Q9NQS7[826-918]
Residue:
93
Sequence:
LNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH
  
Inhibitor
Name:
BDBM50419247
Synonyms:
CHEMBL1835071 | US8470835, 1
Type:
Small organic molecule
Emp. Form.:
C17H22N6O2
Mol. Mass.:
342.3956
SMILES:
Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1 |r|
Structure:
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