| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 1 |
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| Ligand | BDBM1716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
|---|
| pH | 7.3±n/a |
|---|
| Temperature | 298.15±n/a K |
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| IC50 | 10±n/a nM |
|---|
| Comments | extracted |
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| Citation |  Dong, Q; Kaldor, SW MAPK/ERK kinase inhibitors US Patent US8470837 Publication Date 6/25/2013 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 40898.07 |
|---|
| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 372 |
|---|
| Sequence: | PKKKPTPIQLNPAPDGSAVNGTSSAETNLEAFLTQKQKVGELKDDDFEKISELGAGNGGV
VFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISI
CMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSR
GEIKLCDFGVSGQLIDEMANDFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRY
PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEP
PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL
NQPSTPTHAAGV
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| BDBM1716 |
|---|
| Name | BDBM1716 |
|---|
| Synonyms: | CHEMBL1684072 | US8470837, 17 |
|---|
| Type | n/a |
|---|
| Emp. Form. | C16H13F2IN4O3 |
|---|
| Mol. Mass. | 474.2007 |
|---|
| SMILES | Cn1c2ncn(CCO)c(=O)c2c(Nc2ccc(I)cc2F)c(F)c1=O |
|---|
| Structure |  |
|---|
| n/a |
|---|
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