Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM100312
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
8±0
Temperature
301.15±0 K
IC50
3.1±0.0 nM
Citation
 Guo, X; Man, CC; Takahashi, H Azaquinazolinediones chymase inhibitors US Patent  US8501749 Publication Date 8/6/2013 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM100312
Synonyms:
US8501749, 12
Type:
Small organic molecule
Emp. Form.:
C26H22N4O4
Mol. Mass.:
454.4773
SMILES:
Cc1cccc2n(C)cc(Cn3c4ccncc4c(=O)n([C@H](C(O)=O)c4ccccc4)c3=O)c12 |r|
Structure:
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