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TargetChymase
LigandBDBM100314
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
pH8±0
Temperature301.15±0 K
IC50 11±0.0 nM
Citation Guo, XMan, CCTakahashi, H Azaquinazolinediones chymase inhibitors US Patent US8501749 Publication Date 8/6/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Chymase
Name:Chymase
Synonyms:Alpha-chymase | Chymase precursor | Mast cell protease I
Type:Enzyme
Mol. Mass.:27340.12
Organism:Homo sapiens (Human)
Description:n/a
Residue:247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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  Blast E-value cutoff:
BDBM100314
NameBDBM100314
Synonyms:US8501749, 14
TypeSmall organic molecule
Emp. Form.C25H28N4O4
Mol. Mass.448.5142
SMILESCCCCC(Cn1c(=O)n(Cc2cn(C)c3cccc(C)c23)c2ccncc2c1=O)C(O)=O
Structure
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n/a