Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM100317
Substrate
n/a
Meas. Tech.
In Vitro Assay
pH
8±0
Temperature
301.15±0 K
IC50
7±0.0 nM
Citation
 Guo, X; Man, CC; Takahashi, H Azaquinazolinediones chymase inhibitors US Patent  US8501749 Publication Date 8/6/2013 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM100317
Synonyms:
US8501749, 17
Type:
Small organic molecule
Emp. Form.:
C21H20N4O4S
Mol. Mass.:
424.473
SMILES:
CC[C@@H](C(O)=O)n1c(=O)n(Cc2nsc3cc(C)cc(C)c23)c2ccncc2c1=O |r|
Structure:
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