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Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM102307
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±0
IC50
24±0.0 nM
Citation
 Furuyama, H; Goto, Y; Kawanishi, N; Layton, ME; Mita, T; Ogino, Y; Onozaki, Y; Rossi, MA; Sakamoto, T; Sanderson, PE; Wang, J Inhibitors of AKT activity US Patent  US8536193 Publication Date 9/17/2013 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM102307
Synonyms:
US8536193, 3-1
Type:
Small organic molecule
Emp. Form.:
C25H24N6
Mol. Mass.:
408.4983
SMILES:
NC(=N)n1c2cc(-c3ccccc3)c(nc2ccc1=N)-c1ccc(cc1)C1(N)CCC1
Structure:
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