| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ALK2 |
|---|
| Ligand | BDBM50262079 |
|---|
| Substrate/Competitor | n/a |
|---|
| IC50 | 0.67±0.0 nM |
|---|
| Citation |  Mohedas, AH; Xing, X; Armstrong, KA; Bullock, AN; Cuny, GD; Yu, PB Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem Biol8:1291-302 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article |
|---|
| |
| ALK2 |
|---|
| Name: | ALK2 |
|---|
| Synonyms: | ActR-I | ActRIA | Acvr | Acvrlk2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57231.35 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | n/a |
|---|
| Residue: | 509 |
|---|
| Sequence: | MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
AELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
|
|
|
|---|
| BDBM50262079 |
|---|
| n/a |
|---|
| Name | BDBM50262079 |
|---|
| Synonyms: | 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | CHEMBL513147 | LDN-193189 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H22N6 |
|---|
| Mol. Mass. | 406.4824 |
|---|
| SMILES | C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
