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TargetALK4
LigandBDBM36354
Substrate/Competitorn/a
IC50 11023±0.0 nM
Citation Mohedas, AHXing, XArmstrong, KABullock, ANCuny, GDYu, PB Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem Biol8:1291-302 (2013) [PubMed]  Article
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ALK4
Name:ALK4
Synonyms:6820432J04 | ActR-IB | ActRIB | Acvrlk4 | SKR2
Type:n/a
Mol. Mass.:56705.93
Organism:Mus musculus
Description:n/a
Residue:505
Sequence:
MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNYTCETDGACMVSIFNLD
GVEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCNKIDLRVPSGHLKEPAHPS
MWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQ
DLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT
IEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRH
DAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG
GVHEDYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYAN
GAARLTALRIKKTLSQLSVQEDVKI
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  Blast E-value cutoff:
BDBM36354
NameBDBM36354
Synonyms:4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin- 3-yl)quinoline | DMH1 | US9040694, 1
TypeSmall organic molecule
Emp. Form.C24H20N4O
Mol. Mass.380.4418
SMILESCC(C)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a