Target
Lysine-specific demethylase 4A [1-973]
Ligand
BDBM50193145
Substrate
n/a
Meas. Tech.
In vitro Hydroxylation Assays for PHD2 (AlphaScreen)
pH
7.5±0
IC50
>2.0e+4±n/a nM
Citation
 Chowdhury, RCandela-Lena, JIChan, MCGreenald, DJYeoh, KKTian, YMMcDonough, MATumber, ARose, NRConejo-Garcia, ADemetriades, MMathavan, SKawamura, ALee, MKvan Eeden, FPugh, CWRatcliffe, PJSchofield, CJ Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases. ACS Chem Biol 8:1488-96 (2013) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4A [1-973]
Synonyms:
JHDM3A | JMJD2 | JMJD2A | Jumonji domain-containing protein 2A (JMJD2A) | KDM4A | KDM4A_HUMAN | KIAA0677
Type:
PROTEIN
Mol. Mass.:
109792.09
Organism:
Homo sapiens (Human)
Description:
O75164[1-973]
Residue:
973
Sequence:
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVY
  
Inhibitor
Name:
BDBM50193145
Synonyms:
2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid | CHEMBL426560 | Isoquinoline 3 | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Type:
Small organic molecule
Emp. Form.:
C12H9ClN2O4
Mol. Mass.:
280.664
SMILES:
OC(=O)CNC(=O)c1nc(Cl)c2ccccc2c1O
Structure:
Search PDB for entries with ligand similarity: