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TargetHuman diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3)
LigandBDBM103557
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
IC50 1.53e+4± 1.00e+4 nM
Citation Lindgren, AEKarlberg, TThorsell, AGHesse, MSpjut, SEkblad, TAndersson, CDPinto, AFWeigelt, JHottiger, MOLinusson, AElofsson, MSchüler, H PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol8:1698-703 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3)
Name:Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3)
Synonyms:(ARTD3 or PARP3) | ADP-ribosyltransferase diphtheria toxin-like 3 | Poly [ADP-ribose] polymerase 3 | Poly [ADP-ribose] polymerase 3 (PARP-3) | Poly(ADP-ribose) polymerase-3 (ARTD3/PARP3)
Type:PROTEIN
Mol. Mass.:60071.85
Organism:Homo sapiens
Description:n/a
Residue:533
Sequence:
MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNHWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM103557
NameBDBM103557
Synonyms:ME0327
TypeSmall organic molecule
Emp. Form.C19H19N3O2
Mol. Mass.321.3731
SMILESC[C@@H](NC(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccccc1 |r|
Structure
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n/a