Reaction Details
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1-deoxy-D-xylulose-5-phosphate synthase
Ligand
BDBM108231
Substrate
n/a
Meas. Tech.
DXP Synthase Inhibition Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
>2.000e+6±n/a nM
Comments
extracted
Citation
Morris, F; Vierling, R; Boucher, L; Bosch, J; Freel Meyers, CL DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem 14:1309-15 (2013) [PubMed] Article More Info.:
Target
Name:
1-deoxy-D-xylulose-5-phosphate synthase
Synonyms:
1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase)) | DXS_ECOLI | dxs | yajP
Type:
Protein
Mol. Mass.:
67617.17
Organism:
Escherichia coli K-12 (Enterobacteria)
Description:
n/a
Residue:
620
Sequence:
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA
Inhibitor
Name:
BDBM108231
Synonyms:
7‐methoxy‐1‐nitrosonaphthalen‐2‐ol (Substrate 8)
Type:
Small organic molecule
Emp. Form.:
C11H9NO3
Mol. Mass.:
203.1941
SMILES:
COc1ccc2ccc(O)c(N=O)c2c1
Structure:
