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Target
Tyrosine-protein kinase BTK
Ligand
BDBM281754
Substrate
n/a
Meas. Tech.
Human Recombinant Btk Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.073±n/a nM
Comments
extracted
Citation
 Watterson, SH; Tebben, AJ; Ahmad, S Carbazole and tetrahydrocarbazole compounds useful as inhibitors of BTK US Patent  US10023534 Publication Date 7/17/2018 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM281754
Synonyms:
US10023534, Example 13 | US10023534, Example 14
Type:
Small organic molecule
Emp. Form.:
C24H18FN3O2S
Mol. Mass.:
431.482
SMILES:
NC(=O)c1cc(F)c(-c2cccc3N(CCSc23)C(=O)C=C)c2c3ccccc3[nH]c12 |(1.6,6.16,;.26,5.39,;-1.07,6.16,;.26,3.85,;1.6,3.08,;1.6,1.54,;2.93,.77,;.26,.77,;.26,-.77,;-1.07,-1.54,;-1.07,-3.08,;.26,-3.85,;1.6,-3.08,;2.93,-3.85,;4.26,-3.08,;4.26,-1.54,;2.93,-.77,;1.6,-1.54,;2.93,-5.39,;1.6,-6.16,;4.26,-6.16,;5.6,-5.39,;-1.07,1.54,;-2.53,1.06,;-3.16,-.34,;-4.69,-.5,;-5.6,.74,;-4.97,2.15,;-3.44,2.31,;-2.53,3.56,;-1.07,3.08,)|
Structure:
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