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TargetGlucocerebrosidase (Acid beta-Glucosidase)
LigandBDBM108417
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
pH7±0
Ki 3.06± 0.12 nM
IC50 5.8± 0.23 nM
Citation Boyd, RLee, GRybczynski, P Compositions for preventing and/or treating degenerative disorders of the central nervous system US Patent US8604206 Publication Date 12/10/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Glucocerebrosidase (Acid beta-Glucosidase)
Name:Glucocerebrosidase (Acid beta-Glucosidase)
Synonyms:β-glucocerebrosidase (GCase) | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase). | Imiglucerase
Type:Enzyme
Mol. Mass.:59724.64
Organism:Homo sapiens (human)
Description:The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source.
Residue:536
Sequence:
MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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  Blast E-value cutoff:
BDBM108417
n/a
NameBDBM108417
Synonyms:US8604206, 6
TypeSmall organic molecule
Emp. Form.C6H11F2NO2
Mol. Mass.167.1538
SMILESO[C@@H]1CNC[C@H](C(F)F)[C@H]1O
Structure
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