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TargetAurora A/TPX2 (1-43)
LigandBDBM50277545
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay Protocol A
Ki 1.86±0.0 nM
IC50 1780±345 nM
Citation Lavogina, DEnkvist, EViht, KUri, A Long residence times revealed by Aurora A kinase-targeting fluorescent probes derived from inhibitors MLN8237 and VX-689. Chembiochem15:443-50 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora A/TPX2 (1-43)
Name:Aurora A/TPX2 (1-43)
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Serine/threonine-protein kinase Aurora
Synonyms:ARK1 | AURKA | Aurora kinase A | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (human)
Description:n/a
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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Component 2
Name:TPX2 (1-43)
Synonyms:Microtubule-associated
Type:Protein
Mol. Mass.:5046.21
Organism:Homo sapiens (Human)
Description:n/a
Residue:44
Sequence:
MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENK
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BDBM50277545
NameBDBM50277545
Synonyms:4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-ylamino)-2-methoxybenzoic acid | Alisertib | CHEMBL483158 | MLN8237 | US9346787, MLN8237
TypeSmall organic molecule
Emp. Form.C27H20ClFN4O4
Mol. Mass.518.924
SMILESCOc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O |c:11|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a