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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM109232
Substrate
n/a
Meas. Tech.
AlphaScreen Assay (AS)
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
68000±4000 nM
Comments
extracted
Citation
 Lessene, G; Czabotar, PE; Sleebs, BE; Zobel, K; Lowes, KN; Adams, JM; Baell, JB; Colman, PM; Deshayes, K; Fairbrother, WJ; Flygare, JA; Gibbons, P; Kersten, WJ; Kulasegaram, S; Moss, RM; Parisot, JP; Smith, BJ; Street, IP; Yang, H; Huang, DC; Watson, KG Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol 9:390-7 (2013) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM109232
Synonyms:
6-(8-(2-(Benzothiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)picolinic acid (Compound 3) | CHEMBL2398173
Type:
Small organic molecule
Emp. Form.:
C23H18N4O2S
Mol. Mass.:
414.48
SMILES:
OC(=O)c1cccc(n1)-c1ccc2CCCC(=NNc3nc4ccccc4s3)c2c1 |w:17.18|
Structure:
Search PDB for entries with ligand similarity: