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TargetApoptosis Regulator Bcl-xL
LigandBDBM109236
Substrate/Competitorn/a
Meas. Tech.SPR Directy Binding Assay (Biacore 4000)
pH7.4±n/a
IC50 7.1±1.1 nM
Kd 1.4±1.1 nM
Commentsextracted
Citation Lessene, GCzabotar, PESleebs, BEZobel, KLowes, KNAdams, JMBaell, JBColman, PMDeshayes, KFairbrother, WJFlygare, JAGibbons, PKersten, WJKulasegaram, SMoss, RMParisot, JPSmith, BJStreet, IPYang, HHuang, DCWatson, KG Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol9:390-7 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis Regulator Bcl-xL
Name:Apoptosis Regulator Bcl-xL
Synonyms:B-cell lymphoma-extra large protein (Bcl-xL) | BCL-xL | Bcl-2-like protein 1 | Bcl2-L-1
Type:Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:26053.63
Organism:Homo sapiens (Human)
Description:gi_510901
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM109236
NameBDBM109236
Synonyms:WEHI-539
TypeSmall organic molecule
Emp. Form.C31H29N5O3S2
Mol. Mass.583.724
SMILESNCc1ccc(OCCCc2sc(nc2C(O)=O)-c2ccc3CCCC(=NNc4nc5ccccc5s4)c3c2)cc1 |w:26.27|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a