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TargetThrombin-activable fibrinolysis inhibitor (TAFIa)
LigandBDBM109254
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibition Assay
IC50 7.0± 0 nM
Citation Nagata, TInoue, MAshida, YNoguchi, KOno, M Cycloalkyl-substituted imidazole derivative US Patent US8609710 Publication Date 12/17/2013
More Info.:Get all data from this article,  Assay Method
 
Thrombin-activable fibrinolysis inhibitor (TAFIa)
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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BDBM109254
NameBDBM109254
Synonyms:US8609710, 25
TypeSmall organic molecule
Emp. Form.C16H27N3O3
Mol. Mass.309.4039
SMILESC[C@H](CN)OC(Cc1cn(cn1)[C@H]1CC[C@H](C)CC1)C(O)=O |r,wU:12.12,1.0,wD:15.16,(4.54,-1.29,;3.21,-.52,;3.21,1.02,;4.54,1.79,;1.87,-1.29,;1.87,-2.83,;.54,-3.6,;-.79,-2.83,;-.79,-1.29,;-2.26,-.81,;-3.16,-2.06,;-2.26,-3.3,;-2.66,.68,;-4.14,1.07,;-4.54,2.56,;-3.45,3.65,;-3.85,5.14,;-1.97,3.25,;-1.57,1.76,;3.21,-3.6,;3.21,-5.14,;4.54,-2.83,)|
Structure
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