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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM112736
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
41.8±n/a nM
Citation
 Wang, S; Sun, W; Aguilar, A; Garcia-Echeverria, C Spiro-oxindole MDM2 antagonists US Patent  US8629141 Publication Date 1/14/2014 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM112736
Synonyms:
US8629141, 2
Type:
Small organic molecule
Emp. Form.:
C28H30Cl2FN3O3
Mol. Mass.:
546.461
SMILES:
O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21 |r,wU:17.30,18.21,wD:10.10,1.0,(6.05,1.99,;4.57,2.39,;4.17,3.87,;2.68,4.27,;1.59,3.18,;1.99,1.7,;3.48,1.3,;.1,3.58,;-.99,2.49,;-2.47,2.89,;-.59,1.01,;.88,.53,;.88,-1.01,;2.21,-.24,;3.75,-.24,;3.75,-1.78,;2.21,-1.78,;-.59,-1.49,;-1.49,-.24,;-2.98,.16,;-4.07,-.93,;-5.56,-.53,;-5.96,.96,;-4.87,2.04,;-5.26,3.53,;-3.38,1.65,;-3.78,3.13,;.32,-2.73,;1.86,-2.73,;-.59,-3.98,;-2.05,-3.5,;-3.39,-4.27,;-4.72,-3.5,;-6.05,-4.27,;-4.72,-1.96,;-3.39,-1.19,;-2.05,-1.96,)|
Structure:
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