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TargetAlpha-glucosidase A (α-Gal A)
LigandBDBM113757
Substrate/Competitorn/a
Meas. Tech.α-Gal A Assay
pH5±0
IC50 74± 6.4 nM
Citation Yu, YMena-Barragán, TMena-Barragán, KJohnson, JLDrury, JELieberman, RLNakasone, NNinomiya, HTsukimura, TSakuraba, HSuzuki, YNanba, EMellet, COGarcía Fernández, JMGarcía Fernández, K Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human a-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants. ACS Chem Biol9:1460-9 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-glucosidase A (α-Gal A)
Name:Alpha-galactosidase A
Synonyms:Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | INN=Agalsidase | Melibiase
Type:Protein
Mol. Mass.:48760.21
Organism:Homo sapiens (Human)
Description:n/a
Residue:429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM113757
NameBDBM113757
Synonyms:DGJ-pMe OPhT
TypeSmall organic molecule
Emp. Form.C14H20N2O5S
Mol. Mass.328.384
SMILESCOc1ccc(NC(=S)N2C[C@H](O)[C@@H](O)[C@@H](O)[C@H]2CO)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a