Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114305
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1863±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114305
Synonyms:
2,6-Diamino-4-p-tolyl-4H-thiopyran-3,5-dicarbonitrile | 2,6-bis(azanyl)-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile | 2,6-diamino-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile | 2,6-diamino-4-(p-tolyl)-4H-thiopyran-3,5-dicarbonitrile | MLS000072491 | SMR000010366 | cid_600799
Type:
Small organic molecule
Emp. Form.:
C14H12N4S
Mol. Mass.:
268.337
SMILES:
Cc1ccc(cc1)C1C(C#N)C(=N)SC(=N)C1C#N
Structure:
Search PDB for entries with ligand similarity: