Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM42597
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
6886±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM42597
Synonyms:
(Quinolin-2-ylsulfanyl)-acetic acid | 2-(2-quinolinylthio)acetic acid | 2-(2-quinolylthio)acetic acid | 2-quinolin-2-ylsulfanylacetic acid | 2-quinolin-2-ylsulfanylethanoic acid | MLS000029205 | SMR000009740 | cid_408543
Type:
Small organic molecule
Emp. Form.:
C11H9NO2S
Mol. Mass.:
219.26
SMILES:
OC(=O)CSc1ccc2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: