Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM54184
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1364±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM54184
Synonyms:
6,8-bis(bromanyl)-2-methyl-quinolin-3-ol | 6,8-dibromo-2-methyl-3-quinolinol | 6,8-dibromo-2-methyl-quinolin-3-ol | 6,8-dibromo-2-methylquinolin-3-ol | MLS000544929 | SMR000126686 | cid_1472973
Type:
Small organic molecule
Emp. Form.:
C10H7Br2NO
Mol. Mass.:
316.977
SMILES:
Cc1nc2c(Br)cc(Br)cc2cc1O
Structure:
Search PDB for entries with ligand similarity: