Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114332
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1931±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114332
Synonyms:
Isobutyric acid N'-[2-(2-ethyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide | MLS000556743 | N'-[2-(2-ethylquinazolin-4-yl)sulfanylacetyl]-2-methylpropanehydrazide | N'-[2-(2-ethylquinazolin-4-yl)sulfanylethanoyl]-2-methyl-propanehydrazide | N'-[2-[(2-ethyl-4-quinazolinyl)thio]-1-oxoethyl]-2-methylpropanehydrazide | N'-[2-[(2-ethylquinazolin-4-yl)thio]acetyl]-2-methyl-propionohydrazide | SMR000172943 | cid_3192185
Type:
Small organic molecule
Emp. Form.:
C16H20N4O2S
Mol. Mass.:
332.421
SMILES:
CCc1nc(SCC(=O)NNC(=O)C(C)C)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: