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Target
Major prion protein
Ligand
BDBM114443
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1392±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114443
Synonyms:
2-(1-bromanylnaphthalen-2-yl)oxy-N-(5-methyl-1,2-oxazol-3-yl)ethanamide | 2-(1-bromo-2-naphthoxy)-N-(5-methylisoxazol-3-yl)acetamide | 2-(1-bromonaphthalen-2-yl)oxy-N-(5-methyl-1,2-oxazol-3-yl)acetamide | 2-[(1-bromo-2-naphthalenyl)oxy]-N-(5-methyl-3-isoxazolyl)acetamide | MLS002251153 | SMR000835091 | cid_2565490
Type:
Small organic molecule
Emp. Form.:
C16H13BrN2O3
Mol. Mass.:
361.19
SMILES:
Cc1cc(NC(=O)COc2ccc3ccccc3c2Br)no1
Structure:
Search PDB for entries with ligand similarity: