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TargetRibosomal protein S6 kinase (P70S6K)
LigandBDBM116496
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 16200±n/a nM
Commentsextracted
Citation Sutton, AELan, RRichardson, TEPerrey, DVandeveer, HGHuck, BRKarra, SRChen, XXiao, YLiu-Bujalski, LGoutopoulos, AStieber, FHodous, BLQiu, HJones, RHeasley, BH Amino azaheterocyclic carboxamides US Patent US8637532 Publication Date 1/28/2014
More Info.:Get all data from this article,  Assay Method
 
Ribosomal protein S6 kinase (P70S6K)
Name:Ribosomal protein S6 kinase (P70S6K)
Synonyms:70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | Protein kinase 70S6K (T412E) | Ribosomal protein S6 kinase I | S6K1 | p70 S6 ribosomal protein kinase 1 | p70S6K1
Type:Enzyme
Mol. Mass.:59139.89
Organism:Homo sapiens (Human)
Description:His-tagged S6K1.
Residue:525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM116496
NameBDBM116496
Synonyms:US8637532, 177
TypeSmall organic molecule
Emp. Form.C26H21ClF3N5O2
Mol. Mass.527.925
SMILESNC(=O)c1cc(NC(=O)CCc2ccccc2)cc2c(NCc3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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