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Target
Histone deacetylase 1
Ligand
BDBM117192
Substrate
n/a
Meas. Tech.
BIOMOL Fluorescent-Based Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
40±n/a nM
Comments
extracted
Citation
 Lee, KC; Sun, ET; Wang, H Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications US Patent  US8648092 Publication Date 2/11/2014 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM117192
Synonyms:
US8648092, 123
Type:
Small organic molecule
Emp. Form.:
C18H26N4O2
Mol. Mass.:
330.4246
SMILES:
CCCc1nc2cc(\C=C\C(=O)NO)ccn2c1CNC(C)(C)C
Structure:
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