Reaction Details Report a problem with these data
Target
P2Y purinoceptor 12
Ligand
BDBM119428
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
3±n/a nM
Citation
 Nazare, M; Zech, G; Just, M; Weiss, T; Hessler, G; Czech, J Quinoline-carboxamide derivatives as P2Y12 antagonists US Patent  US8669266 Publication Date 3/11/2014 
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM119428
Synonyms:
US8669266, 679
Type:
Small organic molecule
Emp. Form.:
C32H39F3N6O7
Mol. Mass.:
676.6833
SMILES:
Cc1ccc2c(OCC(=O)N3CCC[C@H]3C(=O)NC3CCC3)cc(nc2c1)C(=O)NCC(=O)N1CCN(CC1)C(=O)OCCC(F)(F)F
Structure:
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